In Hungary detailed research work has been carried out since several years to help the process of getting prepared and adapted to the impacts of climate change. The research activities concerned mainly the health impacts of heat waves (excess mortality). Based on the results of the time series statistical analysis of weather variables and daily mortality of Budapest, it was found that a 5ºC increase of the daily mean temperature increases of the risk of all cause mortality by 10%; and the risk of death due to cardio-vascular diseases by 12%. The frequency of heat waves has been increasing since the nineties. The most extreme heat wave hit the country in 2007 with an excess mortality around 1100 cases. A three level heat health warning system was launched in 2005 as an action to support adaptation. A significant association was found between global radiation and the increase of melanoma cases. The incidence of melanoma morbidity increased between 2003– 2008, the number of new cases changed from 1854 to 2610. The data of the previous years support that there is an increasing risk of vector borne diseases, as the continuous increase of the incidence of Lyme diseases (15% per year) showed it. Although tick-borne encephalitis is present in the country, the incidence of the disease does not show a strong correlation with climate variability. Diseases like West Nile virus and Hanta virus infection appeared and showed an increasing tendency. The vector of Leishmaniasis also appeared in Hungary. Another consequence of climate change is the temporal and spatial change of allergenic plant species. New, invasive plants will appear, the length of pollination has been increasing.