REVIEW PAPER
Genetic aspects of obesity and metabolic syndrome in people occupationally exposed to arsenic and certain heavy metals
1
Medical University, Wrocław, Poland
Med Srod. 2019;22(1-2):29-32
KEYWORDS
TOPICS
Environmental toxicology (physical, chemical and biological factors)Health aspects of the work environment
ABSTRACT
Introduction:
Obesity is a common health issue affecting over 650 million people worlwide. It is an integral element of the metabolic syndrome and leads to the development of arterial hypertension and type 2 diabetes, as well as many other different conditions, including numerous tumours. At the same time, exposure to arsenic, cadmium and lead is increasingly attributed to the development of the metabolic syndrome. Environmentally, this influence concerns the entire population, and is particularly visible in the occupationally exposed population.
Objective:
The aim of this study is to prevent selected, best-known elements of the genetic variability and its significance in the development of the metabolic syndrome, taking into account exposure to arsenic, lead and cadmium.
State of the art:
CNR1, FTO are related to an increased risk of developing metabolic syndrome, while certain variants of genes responsible for arsenic metabolism (As3MT) and lead (ALAD) are related to their higher toxicity. Knowledge about the relationship between exposure to arsenic, lead and cadmium, and the polymorphism of genes responsible for the development of the metabolic syndrome is scarce. This gap does not appear in more recent research based on the micro RNA expression. Expression of certain miRNA allows detection of both exposure to arsenic and increased risk of cardiovascular episodes in the future, as well as the existence of organ damage at present.
Conclusions:
Reinforcement and use of the miRNA knowledge appears to be the right direction, but we should not forget current knowledge about polymorphism of individual nucleotides.
Obesity is a common health issue affecting over 650 million people worlwide. It is an integral element of the metabolic syndrome and leads to the development of arterial hypertension and type 2 diabetes, as well as many other different conditions, including numerous tumours. At the same time, exposure to arsenic, cadmium and lead is increasingly attributed to the development of the metabolic syndrome. Environmentally, this influence concerns the entire population, and is particularly visible in the occupationally exposed population.
Objective:
The aim of this study is to prevent selected, best-known elements of the genetic variability and its significance in the development of the metabolic syndrome, taking into account exposure to arsenic, lead and cadmium.
State of the art:
CNR1, FTO are related to an increased risk of developing metabolic syndrome, while certain variants of genes responsible for arsenic metabolism (As3MT) and lead (ALAD) are related to their higher toxicity. Knowledge about the relationship between exposure to arsenic, lead and cadmium, and the polymorphism of genes responsible for the development of the metabolic syndrome is scarce. This gap does not appear in more recent research based on the micro RNA expression. Expression of certain miRNA allows detection of both exposure to arsenic and increased risk of cardiovascular episodes in the future, as well as the existence of organ damage at present.
Conclusions:
Reinforcement and use of the miRNA knowledge appears to be the right direction, but we should not forget current knowledge about polymorphism of individual nucleotides.
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