REVIEW PAPER
Obesity as an important risk factor for dementia
1
Military Clinical Hospital No. 1 with Polyclinic, Independent Public Health Care Unit, Lublin, Poland
2
Jana Pawła II Clinical Hospital, Kraków, Poland
3
Military Clinical Hospital No. 5 with Polyclinic, Independent Public Health Care Unit, Kraków, Poland
Corresponding author
Laura Fus-Mazurkiewicz
Military Clinical Hospital No. 1 with Polyclinic, Independent Public Health Care Unit, Lublin, Poland
Military Clinical Hospital No. 1 with Polyclinic, Independent Public Health Care Unit, Lublin, Poland
Med Srod. 2023;26(3-4):79-83
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
Obesity is a disease that affects an increasing number of people worldwide. Simultaneously, it is also predisposing in the development of many conditions, including dementia. There are an alarming number of obese people worldwide, and the risk of people suffering from dementia will continue to increase annually. The aim of this review is to draw attention to issues related to obesity as a predisposition to the development of dementia, including factors contributing to the development of both of these diseases.
Abbreviated description of the state of knowledge:
There are a number of factors that may contribute to the development of obesity. These include: socio-economic status, appearance preferences, the influence of the external environment, and many others. Obesity is associated with hormonal disorders, including increase in leptin levels and increased production of adipokines. Both of these phenomena adversely affect the central nervous system, leading to the development of inflammatory reactions, and apoptosis of neuronal cells. It will significantly contribute to the impairment of the functioning of the nervous system, favouring the development of numerous diseases, including dementia.
Summary:
Obesity is an increasingly serious problem, especially in developed countries. It leads to a number of disorders in the human body which have an impact on the high risk of dementia diseases. There are numerous factors predisposing to the development of both obesity and dementia and there seems to be a clear correlation between the two diseases.
Obesity is a disease that affects an increasing number of people worldwide. Simultaneously, it is also predisposing in the development of many conditions, including dementia. There are an alarming number of obese people worldwide, and the risk of people suffering from dementia will continue to increase annually. The aim of this review is to draw attention to issues related to obesity as a predisposition to the development of dementia, including factors contributing to the development of both of these diseases.
Abbreviated description of the state of knowledge:
There are a number of factors that may contribute to the development of obesity. These include: socio-economic status, appearance preferences, the influence of the external environment, and many others. Obesity is associated with hormonal disorders, including increase in leptin levels and increased production of adipokines. Both of these phenomena adversely affect the central nervous system, leading to the development of inflammatory reactions, and apoptosis of neuronal cells. It will significantly contribute to the impairment of the functioning of the nervous system, favouring the development of numerous diseases, including dementia.
Summary:
Obesity is an increasingly serious problem, especially in developed countries. It leads to a number of disorders in the human body which have an impact on the high risk of dementia diseases. There are numerous factors predisposing to the development of both obesity and dementia and there seems to be a clear correlation between the two diseases.
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