REVIEW PAPER
Volatile organic compounds in pharmacy – the range of the problem
1
Katedra i Zakład Chemii Fizycznej
Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej Kierownik Katedry: prof. dr hab. W. Sawicki Dziekan Wydziału Farmaceutycznego z OML GUMed: prof. dr hab. W. Sawicki
Corresponding author
Marzena Jamrógiewicz
Katedra i Zakład Chemii Fizycznej Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej Kierownik Katedry: prof. dr hab. W. Sawicki Dziekan Wydziału Farmaceutycznego z OML GUMed: prof. dr hab. W. Sawicki
Katedra i Zakład Chemii Fizycznej Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej Kierownik Katedry: prof. dr hab. W. Sawicki Dziekan Wydziału Farmaceutycznego z OML GUMed: prof. dr hab. W. Sawicki
Med Srod. 2013;16(3):59-68
KEYWORDS
ABSTRACT
The sensitivity and chemical instability of the active pharmaceutical ingredients (API) may result in the formation and emission of volatile substances which affect not only the stability of the medicinal product, but also leads to changes of physicochemical properties, causing negative pharmacologic effects sometimes toxic. For this reason, it is important to conduct routine stability tests, as well as, to determine gaseous degradation products using modern analytical methods, often unconventional. Knowledge of medicinal chemistry, physical chemistry, technology and toxicology is needed to provide a stable form of the drug and its utmost therapeutic effect. Available guidelines on determined volatile organic compounds (VOCs) present in samples of drug substances have been verified , types of VOCs have been specified and classified. Current literature reviewed shows the results of determination of VOCs in active drug compounds and medicinal products, including discussion on various possibilities of their detection and identification. Currently used methods are based on gas chromatography and ion mobility spectrometry IMS.
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