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Wprowadzenie i cel:
W krajach zurbanizowanych alergia pokarmowa u niemowląt jest poważnym problemem zdrowotnym, którego częstość występowania rośnie i który stanowi wyzwanie zarówno dla rodziców, jak i lekarzy. W pierwszych miesiącach życia dziecka jego organizm jest szczególnie wrażliwy na reakcje alergiczne, dlatego znajomość czynników ryzyka jest kluczowa dla zapobiegania alergii i zarządzania tą problematyką zdrowotną. Celem niniejszej pracy jest zbadanie wpływu sposobu karmienia niemowląt na rozwój alergii pokarmowej, ze szczególnym uwzględnieniem karmienia mlekiem kobiecym oraz mlekiem modyfikowanym, a także sposobu rozszerzania diety oraz suplementacji witaminą D i probiotykami. Przedstawia również potencjalne korzyści i ograniczenia poszczególnych metod.

Opis stanu wiedzy:
W badaniach naukowych widoczna jest istotna zależność między pozytywnym wpływem karmienia piersią na prawidłowy rozwój mikrobiomu przewodu pokarmowego u niemowląt, co wiąże się ze zmniejszonym ryzykiem rozwoju alergii pokarmowej. Natomiast wpływ karmienia mlekiem modyfikowanym, a także suplementacji witaminą D jest niejasny i jest zależy od wielu zmiennych. Odpowiednia suplementacja probiotykami może mieć korzystny wpływ na prawidłowy rozwój mikrobiomu jelitowego, a tym samym na redukcję ryzyka wystąpienia alergii pokarmowej. Nie należy unikać ani opóźniać wprowadzania produktów w celu prewencji alergii pokarmowej u niemowląt.

Podsumowanie:
Zastosowanie odpowiednich metod żywieniowych może zmniejszyć ryzyko wystąpienia alergii pokarmowej u niemowląt. Jednakże potrzebne są dalsze badania nad skutecznością tych działań oraz ich optymalnymi strategiami w ramach kompleksowej opieki nad niemowlętami.


Introduction and objective:
Food allergy in infants is a major health problem in urbanised countries, the incidence of which is increasing and is a challenge for both parents and doctors. In the first months of life, a child’s body is particularly sensitive to allergic reactions, therefore knowing the risk factors is crucial for the prevention and management of this health problem.

Objective:
The aim of this study is to examine the impact of infant feeding on the development of food allergies, with particular emphasis on breastfeeding, formula milk, the method of expanding the diet, vitamin D supplementation and probiotics. The potential benefits and limitations of each method be presented.

Abbreviated description of the state of knowledge:
In scientific studies, there is a significant indication of the positive impact of breastfeeding on the proper development of the infant’s intestinal microbiome, which is associated with a reduced risk of developing food allergies. However, the effect of formula feeding, as well as vitamin D supplementation, remains unclear and depends on many variables. Appropriate supplementation with probiotics may have a beneficial effect on the proper development of the intestinal microbiome, thereby reducing the risk of food allergies. It is not recommended to avoid or delay the introduction of allergenic foods to infants.

Summary:
The use of appropriate infant feeding methods may reduce the risk of food allergy in infants. However, further research is needed on the effectiveness of these interventions and their optimal strategies as part of comprehensive infant care.

REFERENCJE (44)
1.
Tedner SG, Asarnoj A, Thulin H, et al. Food allergy and hypersensitivity reactions in children and adults-A review. J Intern Med. 2022 Mar;291(3):283–302. https://doi.org/10.1111/joim.1....
 
2.
Yu W, Freeland DMH, Nadeau KC. Food allergy: immune mechanisms, diagnosis and immunotherapy. Nat Rev Immunol. 2016 Dec;16(12):751–765. https://doi.org/10.1038/nri.20....
 
3.
Barni S, Liccioli G, Sarti L, et al. Immunoglobulin E (IgE)-Mediated Food Allergy in Children: Epidemiology, Pathogenesis, Diagnosis, Prevention, and Management. Medicina (Kaunas). 2020 Mar 4;56(3):111. https://doi.org/10.3390/medici....
 
4.
Sampath V, Abrams EM, Adlou B, et al. Food allergy across the globe. J Allergy Clin Immunol. 2021 Dec;148(6):1347–1364. https://doi.org/10.1016/j.jaci....
 
5.
Xepapadaki P, Fiocchi A, Grabenhenrich L, et al. Incidence and natural history of hen’s egg allergy in the first 2 years of life-the EuroPrevall birth cohort study. Allergy. 2016 Mar;71(3):350–7. https://doi.org/10.1111/all.12....
 
6.
Schoemaker AA, Sprikkelman AB, Grimshaw KE, et al. Incidence and natural history of challenge-proven cow’s milk allergy in European children--EuroPrevall birth cohort. Allergy. 2015 Aug;70(8):963–72. https://doi.org/10.1111/all.12....
 
7.
World Health Organization. Exclusive Breastfeeding for Six Months Best for Babies Everywhere. Available online: https://www.who.int/news/item/... (accessed on 10 September 2024).
 
8.
Gupta A, Suri S, Dadhich JP, et al. The World Breastfeeding Trends Initiative: Implementation of the Global Strategy for Infant and Young Child Feeding in 84 countries. J Public Health Policy. 2019 Mar;40(1):35–65. https://doi.org/10.1057/s41271....
 
9.
Munblit D, Peroni DG, Boix-Amorós A, et al. Human Milk and Allergic Diseases: An Unsolved Puzzle. Nutrients. 2017 Aug 17;9(8):894. https://doi.org/10.3390/nu9080....
 
10.
Ohsaki A, Venturelli N, Buccigrosso TM, et al. Maternal IgG immune complexes induce food allergen-specific tolerance in offspring. J Exp Med. 2018 Jan 2;215(1):91–113. https://doi.org/10.1084/jem.20....
 
11.
Sakanaka M, Gotoh A, Yoshida K, et al. Varied Pathways of Infant Gut-Associated Bifidobacterium to Assimilate Human Milk Oligosaccharides: Prevalence of the Gene Set and Its Correlation with Bifidobacteria-Rich Microbiota Formation. Nutrients. 2019 Dec 26;12(1):71. https://doi.org/10.3390/nu1201....
 
12.
Laursen MF, Sakanaka M, von Burg N, et al. Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut. Nat Microbiol. 2021 Nov;6(11):1367–1382. https://doi.org/10.1038/s41564....
 
13.
Wang S, Wei Y, Liu L, et al. Association Between Breastmilk Microbiota and Food Allergy in Infants. Front Cell Infect Microbiol. 2022 Jan 12;11:770913. https://doi.org/10.3389/fcimb.....
 
14.
Henrick BM, Rodriguez L, Lakshmikanth T, et al. Bifidobacteria-mediated immune system imprinting early in life. Cell. 2021 Jul 22;184(15):3884–3898.e11. https://doi.org/10.1016/j.cell....
 
15.
Fujimura KE, Sitarik AR, Havstad S, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med. 2016 Oct;22(10):1187–1191. https://doi.org/10.1038/nm.417....
 
16.
Wang Z, Neupane A, Vo R, et al. Comparing Gut Microbiome in Mothers’ Own Breast Milk- and Formula-Fed Moderate-Late Preterm Infants. Front Microbiol. 2020 May 26;11:891. https://doi.org/10.3389/fmicb.....
 
17.
Lee SA, Lim JY, Kim BS, et al. Comparison of the gut microbiota profile in breast-fed and formula-fed Korean infants using pyrosequencing. Nutr Res Pract. 2015 Jun;9(3):242–8. https://doi.org/10.4162/nrp.20....
 
18.
Wallingford JC, Neve Myers P, Barber CM. Effects of addition of 2-fucosyllactose to infant formula on growth and specific pathways of utilization by Bifidobacterium in healthy term infants. Front Nutr. 2022 Sep 23;9:961526. https://doi.org/10.3389/fnut.2....
 
19.
Holst AQ, Myers P, Rodríguez-García P, et al. Infant Formula Supplemented with Five Human Milk Oligosaccharides Shifts the Fecal Microbiome of Formula-Fed Infants Closer to That of Breastfed Infants. Nutrients. 2023 Jul 10;15(14):3087. https://doi.org/10.3390/nu1514....
 
20.
Zepeda-Ortega B, Goh A, Xepapadaki P, et al. Strategies and Future Opportunities for the Prevention, Diagnosis, and Management of Cow Milk Allergy. Front Immunol. 2021 Jun 10;12:608372. https://doi.org/10.3389/fimmu.....
 
21.
Chatchatee P, Nowak-Wegrzyn A, Lange L, et al. PRESTO study team. Tolerance development in cow’s milk-allergic infants receiving amino acid-based formula: A randomized controlled trial. J Allergy Clin Immunol. 2022 Feb;149(2):650–658.e5. https://doi.org/10.1016/j.jaci....
 
22.
Halken S, Muraro A, de Silva D, et al. European Academy of Allergy and Clinical Immunology Food Allergy and Anaphylaxis Guidelines Group. EAACI guideline: Preventing the development of food allergy in infants and young children (2020 update). Pediatr Allergy Immunol. 2021 Jul;32(5):843–858. https://doi.org/10.1111/pai.13....
 
23.
Agostoni C, Decsi T, Fewtrell M, et al. ESPGHAN Committee on Nutrition:. Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2008 Jan;46(1):99–110. https://doi.org/10.1097/01.mpg....
 
24.
Ferraro V, Zanconato S, Carraro S. Timing of Food Introduction and the Risk of Food Allergy. Nutrients. 2019 May 21;11(5):1131. https://doi.org/10.3390/nu1105....
 
25.
Szajewska H, Socha P, Horvath A, et al. Nutrition of healthy term infants. Recommendations of the Polish Society for paediatrics gastroenterology, hepatology and nutrition. Pediatric Rev. 2021; 50(2), 17–37. http://dx.doi.org/10.5281/zeno....
 
26.
Sicherer SH, Warren CM, Dant C, et al. Food Allergy from Infancy Through Adulthood. J Allergy Clin Immunol Pract. 2020 Jun;8(6):1854–1864. https://doi.org/10.1016/j.jaip....
 
27.
Peters RL, Koplin JJ, Gurrin LC, et al. HealthNuts Study. The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up. J Allergy Clin Immunol. 2017 Jul;140(1):145–153.e8. https://doi.org/10.1016/j.jaci....
 
28.
Ierodiakonou D, Garcia-Larsen V, Logan A, et al. Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease: A Systematic Review and Meta-analysis. JAMA. 2016 Sep 20;316(11):1181–1192. https://doi.org/10.1001/jama.2....
 
29.
Du Toit G, Roberts G, Sayre PH, et al. LEAP Study Team. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015 Feb 26;372(9):803–13. https://doi.org/10.1056/nejmoa....
 
30.
EAT Study Team. Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants. N Engl J Med. 2016 May 5;374(18):1733–43. https://doi.org/10.1056/10.105....
 
31.
W Ao T, Kikuta J, Ishii M. The Effects of Vitamin D on Immune System and Inflammatory Diseases. Biomolecules. 2021 Nov 3;11(11):1624. https://doi.org/10.3390/biom11....
 
32.
Psaroulaki E, Katsaras GN, Samartzi P, et al. Association of food allergy in children with vitamin D insufficiency: a systematic review and meta-analysis. Eur J Pediatr. 2023 Apr;182(4):1533–1554. https://doi.org/10.1007/s00431....
 
33.
Rueter K, Jones AP, Siafarikas A, et al. In “High-Risk” Infants with Sufficient Vitamin D Status at Birth, Infant Vitamin D Supplementation Had No Effect on Allergy Outcomes: A Randomized Controlled Trial. Nutrients. 2020 Jun 11;12(6):1747. https://doi.org/10.3390/nu1206....
 
34.
Shadid IL, Brustad N, Lu M, et al. The Impact of Baseline 25-Hydroxy -vitamin D Level and Gestational Age on Prenatal Vitamin D Supplementation to Prevent Offspring Asthma or Recurrent Wheezing. Am J Clin Nutr. 2023 Jun;117(6):1342–1352. https://doi.org/10.1016/j.ajcn....
 
35.
Lu M, Litonjua AA, O’Connor GT, et al. Effect of early and late prenatal vitamin D and maternal asthma status on offspring asthma or recurrent wheeze. J Allergy Clin Immunol. 2021 Apr;147(4):1234–1241.e3. https://doi.org/10.1016/j.jaci....
 
36.
Feketea G, Kostara M, Bumbacea RS, et al. Vitamin D and Omega-3 (Fatty Acid) Supplementation in Pregnancy for the Primary Prevention of Food Allergy in Children-Literature Review. Children (Basel). 2023 Feb 27;10(3):468. https://doi.org/10.3390/childr....
 
37.
Płudowski P, Kos-Kudła B, Walczak M, et al. Guidelines for Preventing and Treating Vitamin D Deficiency: A 2023 Update in Poland. Nutrients. 2023 Jan 30;15(3):695. https://doi.org/10.3390/nu1503....
 
38.
National Institutes of Health. Vitamin D. Fact Sheet for Health Professionals. Available online: https://ods.od.nih.gov/factshe... (acessed on 10 September 2024).
 
39.
Wang J, Zhu N, Su X, et al. Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis. Cells. 2023 Mar 2;12(5):793. https://doi.org/10.3390/cells1....
 
40.
Scudellari M. News Feature: Cleaning up the hygiene hypothesis. Proc Natl Acad Sci USA. 2017 Feb 14;114(7):1433–1436. https://doi.org10.1073/pnas.17....
 
41.
Poto R, Fusco W, Rinninella E, et al. The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy. Nutrients. 2023 Dec 27;16(1):92. https://doi.org/10.3390/nu1601....
 
42.
Cukrowska B, Ceregra A, Maciorkowska E, et al. The Effectiveness of Probiotic Lactobacillus rhamnosus and Lactobacillus casei Strains in Children with Atopic Dermatitis and Cow›s Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study. Nutrients. 2021 Apr 1;13(4):1169. https://doi.org/10.3390/nu1304....
 
43.
Zhang GQ, Hu HJ, Liu CY, et al. Probiotics for Prevention of Atopy and Food Hypersensitivity in Early Childhood: A PRISMA-Compliant Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore). 2016 Feb;95(8):e2562. https://doi.org/10.1097/MD.000....
 
44.
Tang ML, Ponsonby AL, Orsini F, et al. Administration of a probiotic with peanut oral immunotherapy: A randomized trial. J Allergy Clin Immunol. 2015 Mar;135(3):737–44.e8. https://doi.org/10.1016/j.jaci....
 
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